USA vs. Panama: CONCACAF Nations League Semifinals Preview

The first semifinal of the CONCACAF Nations League is set to take place, with the USA hosting Panama in California in a single-leg match for a spot in the tournament final.

The United States dominantly advanced to this stage, crushing Jamaica with a 5-2 aggregate score, winning both matches.

Meanwhile, Panama had a tougher road. After securing a 1-0 away victory against Costa Rica, they drew 2-2 in the second leg and advanced with a 3-2 aggregate score.

United States and Panama will meet at the SoFi Stadium next Thursday, March 20, for the semifinals of the CONCACAF Nations League.

USA vs. Panama Betting Odds and Info

Why Bet on USA?

Today, the United States is the dominant powerhouse in CONCACAF. It’s no coincidence that this tournament has been held three times before, and the ‘Stars and Stripes’ have won all three editions, defeating Mexico in two finals.

Without a doubt, they are the clear favorites to win this matchup. In the semifinals, they first defeated Jamaica 1-0 in Kingston with a goal from Ricardo Pepi, then secured a 4-2 victory in the second leg.

So far in 2025, they have played two friendly matches, beating Venezuela 3-1 and Costa Rica 3-0—a team with a level similar to Panama’s. On that occasion, Mauricio Pochettino’s squad was made up of MLS players.

Some of the team’s biggest stars include Christian Pulisic, Weston McKennie, Antonee Robinson, Yunus Musah, Giovanni Reyna, and Timothy Weah. However, in the squad, there are a lot of players from the local league.

¿Por qué apostar por Panamá?

Panama has reached its third consecutive CONCACAF Nations League semifinal, but this time, they hope to pull off the tournament’s biggest upset by eliminating the heavy favorites and advancing to their first-ever final.

Their quarterfinal journey was tough. They secured a 1-0 away win against Costa Rica thanks to a penalty from José Fajardo. They then drew 2-2 in the second leg, with Orlando Mosquera making a crucial penalty save early in the match.

However, the ‘Canaleros’ have not shown great form. In 2025, they played two friendly matches and lost both—first to Peru’s Universitario (2-1) and then suffered a crushing 6-1 defeat against Chile. Spanish coach Thomas Christiansen has plenty of work to do.

Adalberto Carrasquilla, last season’s CONCACAF Player of the Year, is the team’s biggest star, especially after the recent injury to Olympique Marseille’s right-back Michael Murillo, who suffered a hamstring injury on March 2 in the French league. Murillo joins Yoel Bárcenas, sidelined with a knee injury since last month, and Fidel Escobar, who is suspended.

In addition to Carrasquilla, key players include the experienced Aníbal Godoy and Cecilio Waterman, as well as José Córdoba and César Blackman, who bring European experience to the squad.

Análisis final de apuestas: Estados Unidos vs.Panamá

The United States is the heavy favorite due to the squad’s depth, history, past tournament performances, and home advantage. While Panama has pulled off some surprises recently, we don’t see that happening this time—expect the Americans to win 2-1.

The odds at Gambyl Exchange favor the United States, with their Moneyline set at 1.37, Panama at 8.4, and a draw at 4.9.

The last time these two teams met was on October 12 of last year in a friendly match, in which the U.S. won 2-0. However, in their most recent official game, Panama secured a 2-1 victory in the 2024 Copa América. Before that, in the 2023 Gold Cup, they drew 1-1, with the Central Americans winning on penalties.

Go for a win for the United States. If you bet $100 at 1.37, you will gain $37 for a total payout of $137.

United States vs. Panama Betting Pick: EE.UU