Premier League Matchday 12 Betting Favorites

Last Updated on November 21, 2025 10:08 am by Erwin Noguera

The Premier League returns after the last international break of the year, and it does so with a matchday 12 packed with key clashes and direct implications at the top and bottom of the table.

Arsenal arrive as clear leaders, six points ahead of Manchester City, who are coming off a win over Liverpool to take second place. Now, the Gunners face a new chapter in the North London Derby against a Tottenham side that has lost momentum after a promising start.

Saturday kicks off with action at Turf Moor, where Burnley host Chelsea to kick off a day full of soccer with seven consecutive matches. At the same time, Liverpool will try to end their recent slump when they host Nottingham Forest at Anfield, having lost three of their last five games in all competitions. The weekend promises to be exciting, especially for teams looking for stability in an increasingly demanding schedule.

The round will close on Monday at Old Trafford, where Manchester United will look to extend their unbeaten run to six games against an Everton side needing points. With a group of five teams tied on 18 points, any win could mean a significant climb up the table. With this in mind, let’s take a look at the previews for the weekend’s top matches.

At Gambyl Exchange, you can explore all the predictions for the Premier League, the final bets for this matchday, and the odds for each match.

Premier League Weekly Picks Betting Odds

Premier League Matchday 12: Burnley vs. Chelsea

Burnley returns to Turf Moor needing to respond. With just 10 points and sitting in 17th place, Scott Parker’s team is struggling to find the consistency to move away from the relegation zone. Their recent defeat to West Ham once again highlighted the team’s difficulties in competing away from home, reflecting a worrying trend that has marked their start to the season. With only three wins in eleven games, the pressure is mounting, and this clash against an elite opponent comes at an awkward time.

On the other side, Chelsea arrives in Lancashire in a much more favorable position. Third in the table with 20 points, Enzo Maresca’s side has found a convincing style of play, backed up by six wins and an increasingly solid defensive performance. Their recent victory over Wolves not only reaffirmed their good form but also boosted the confidence of the dressing room as they sprint towards the top of the table.

The recent history between the two clubs is largely in Chelsea’s favor: the Blues have comfortably dominated their head-to-head encounters. Even so, Burnley tend to compete better at home, although they will need to be at their best to prevent the game from going the way of the favorites. In terms of squad, form, and momentum, the Londoners have the advantage.

Burnley vs. Chelsea Betting Pick: Chelsea

Premier League Matchday 12: Liverpool vs. Nottingham Forest

At Anfield, Liverpool faces a crucial match after a difficult stretch of the season. Arne Slot’s team is eighth with 18 points and has suffered three defeats in its last five games. Its most recent setback, a 3-0 loss to Manchester City, highlighted the need to improve defensively and regain its offensive spark. However, at home, the picture is different: four wins in five games give hope for a comeback this weekend.

Nottingham arrives in Merseyside in an even more delicate situation. Second from bottom with nine points, Sean Dyche’s side have shown a slight upturn with two wins and two draws in their last five games. Even so, their away form remains a problem: they have yet to win an away game this season. Forest competes, but they are unable to translate their efforts into results.

The last meeting between the two sides ended in a draw, a sign that Forest does not usually make things easy for Liverpool. However, playing at Anfield and the Reds’ urgent need to get back on track make them favorites. A slip-up at home would heighten doubts; a win could mark the beginning of a recovery.

Liverpool vs. Nottingham Forest Betting Pick: Liverpool

Premier League Matchday 12: Newcastle vs. Manchester City

Newcastle is still struggling to find a winning streak that will propel them to higher positions in the table. With just 12 points and sitting in 14th place, Eddie Howe’s team has had an inconsistent performance, especially in attack. Their home record is acceptable, with three wins in five games, but recent defeats show that the team is still struggling to regain the solidity it displayed in previous seasons.

In contrast, City arrives in northern England in a very different form. Pep Guardiola’s side is second with 22 points and is coming off a key win against Liverpool. Its offense remains one of the most feared in the league, with 23 goals scored, and its defense, except for a few isolated lapses, remains among the most reliable in the league. City has already shown that, even in difficult games, it has more than enough tools to impose its will.

The last time they met, the Citizens crushed Newcastle 4-0, a result that still weighs heavily on the Magpies. Although St James’ Park can be an uncomfortable venue, the current difference in level between the two teams is evident. The home side will have to play a near-perfect game to withstand one of the most finely tuned offenses in the tournament.

Newcastle vs. Manchester City Betting Pick: Manchester City

Premier League Matchday 12: Arsenal vs. Tottenham

The league leaders return to the Emirates for one of the most tense matches of the season: the North London Derby. With 26 points and a solid start to the campaign (eight wins, two draws, and just one defeat), Mikel Arteta’s side have been strong both at home and away. Their home record is outstanding: four wins and one draw, backed up by a defense that has proven very difficult to break down.

The Spurs, meanwhile, arrive weakened after a recent run that has seen them lose momentum. Despite clinching fifth place with 18 points, their promising start has been overshadowed by just one win in their last four games. That said, their away form has been remarkable: four wins and one draw away from home. The challenge at the Emirates, however, is on another level.

Tottenham won the last head-to-head match, which adds an interesting emotional component, but both teams are coming off draws in their previous games, and the pressure is on the visitors, who need to rediscover their form. Arsenal, better equipped and more consistent, are in a better position to dominate the game and defend their lead.

Arsenal vs. Tottenham Betting Pick: Arsenal