Premier League Matchday 22 Betting Favorites

Last Updated on January 14, 2026 12:57 pm by Erwin Noguera

Matchday 22 of the Premier League arrives with the title race still tightly contested at the top, and this weekend also features another Manchester derby.

United hosts a City side that must win to avoid falling further behind Arsenal, who will visit a Nottingham Forest team increasingly close to the relegation zone.

Aston Villa, third in this battle, will host Everton, while Liverpool is gradually closing the gap and faces what appears to be a favorable task when they welcome Burnley at Anfield.

At Gambyl Exchange, you can explore all the predictions for the Premier League, the final bets for this matchday, and the odds for each match.

Premier League Weekly Picks Betting Odds

Premier League Matchday 22: Manchester United vs. Manchester City

Manchester United continue to struggle and have chosen Michael Carrick to steer the ship until the end of the season. The former midfielder managed Middlesbrough from 2022 to 2025, recording 63 wins, 24 draws, and 49 losses, and now arrives at a team that has drawn three straight league matches, two of them against sides in the relegation zone, and is coming off a home elimination in the FA Cup versus Brighton (1–2). They sit seventh with 31 points, just one away from the Europa League places.

Manchester City, meanwhile, are second with 43 points, six behind Arsenal. Like their rivals, they also have three consecutive league draws, but before that, they had won six straight matches. Overall, City are unbeaten in 13 games across all competitions, winning 10 of them, including an away victory over Real Madrid in the Champions League and a 10–1 win over Exeter in the FA Cup last weekend.

Erling Haaland is the league’s top scorer with 20 goals, but he has found the net only once in his last six matches, including the game against Exeter, and that goal came from the penalty spot. Antoine Semenyo arrived and registered a goal and an assist in his debut, followed by another goal against Newcastle in the EFL Cup (0–2).

Manchester United vs. Manchester City Betting Pick: Draw

Premier League Matchday 22: Liverpool vs. Burnley

After a major results crisis, Liverpool has been improving, although it is still far from where they want to be.They are on a nine-match unbeaten run in the Premier League, though five of those have been draws, including their most recent 0–0 result away to league leaders Arsenal in London. They sit fourth with 35 points and have just eliminated Barnsley 4–1, with another goal and an assist from Florian Wirtz, who has three goals in his last five matches and is beginning to show his best form.

Burnley do not want to be stuck in the up-and-down cycle of promotion and relegation, but it seems they do not quite have enough to break out of it. They are 19th with 13 points, eight adrift of 17th place. They have gone 12 matches without a win, accumulating only three points during this period. Their most recent game ended in a 2–2 draw against Manchester United. However, as visitors, they have secured just four out of a possible 30 points.

Liverpool vs. Burnley Betting Pick: Liverpool

Premier League Matchday 22: Forest vs. Arsenal

Nottingham Forest have avoided falling into the relegation zone largely because West Ham have been in poor form.They sit 17th with 21 points, seven clear of 18th place. They had suffered four straight defeats before snapping the streak in the previous matchday, precisely against the ‘Hammers’, beating them 1–2 away from home with an 89th-minute penalty. They are also coming off an FA Cup elimination on penalties against Wrexham.

Arsenal lead the Premier League with 49 points, six ahead of Manchester City and Aston Villa. They had won five straight league matches, but were held to a scoreless draw at home in their most recent league game against Liverpool. They had no trouble defeating Portsmouth in the FA Cup, with a hat trick from Gabriel Martinelli, who this season has just one league goal but five in the Champions League. Kai Havertz played his first minutes since August 17.

Forest vs. Arsenal Betting Pick: Arsenal

Premier League Matchday 22: Aston Villa vs. Everton

Aston Villa remain in the title race.With 43 points, they sit third, level with second place and six points off the top. In recent matchdays, they have slightly lost momentum, collecting four of the last nine points available; however, they have lost just one of their previous 15 matches, winning 13 of them. Ollie Watkins had scored four goals in three matches before his streak ended in the most recent game, a scoreless draw against Crystal Palace.

Everton sit in mid-table, exactly 12th with 29 points. They have recorded eight wins, five draws, and eight losses, scoring 23 goals and conceding 25. They have won just one of their last seven matches, including their most recent FA Cup tie against Sunderland, where they were eliminated on penalties. They are not a poor away side, having collected 14 of a possible 30 points on the road.

Aston Villa vs. Everton Betting Pick: Aston Villa