Premier League Matchday 21 Betting Favorites

Last Updated on January 5, 2026 3:54 pm by Erwin Noguera

The Premier League enters matchday 21 with the championship wide open and a schedule that offers no respite. January has always been a decisive month in England, where physical wear and tear, rotations, and squad depth begin to make a real difference between contenders and pursuers. This matchday also features several direct clashes that could alter the fight for the title and European places.

While some teams are looking to consolidate their position at the top, others face this matchday with an urgent need to pick up points to avoid getting caught in a deceptive mid-table, where a bad run can drag anyone into bigger problems. The Premier League knows no hierarchy when the pace is high, and the games come thick and fast.

Matchday 21 presents a perfect balance between high-voltage duels and tricky matches. From Aston Villa’s visit to Selhurst Park to the star-studded clash between Arsenal and Liverpool at the Emirates, the menu is varied and demanding. Each match has its own context and a story that could leave its mark on the rest of the season.

At Gambyl Exchange, you can explore all the predictions for the Premier League, the final bets for this matchday, and the odds for each match.

Premier League Weekly Picks Betting Odds

Premier League Matchday 21: Crystal Palace vs. Aston Villa

Crystal Palace is going through a difficult period. Sitting in the lower-middle of the table, Oliver Glasner’s team has lost its fluidity and confidence, especially in recent games. Although it is not a team that concedes too many goals, its main problem is its lack of incisiveness in closing out games, something that has been even more pronounced when playing at home.

Selhurst Park is no longer the refuge it has been in previous seasons. Palace competes, presses, and stays in games, but struggles to turn that effort into wins. Against an opponent in top form, they will need a near-perfect performance to get something out of the game.

Aston Villa arrives with an opposite dynamic. Unai Emery’s team has established itself as one of the most reliable teams in the league, combining tactical discipline with firepower. Its competitive maturity and ability to handle different scenarios make it a difficult opponent, even away from Birmingham.

Crystal Palace vs. Aston Villa Betting Pick: Aston Villa

Premier League Matchday 21: Fulham vs. Chelsea

Fulham has built a remarkable season based on stability. Without much fanfare, Marco Silva’s team has become strong at home and has been able to compete against rivals with bigger budgets.Their recent good run reflects a confident, well-organized team with the ability to punish mistakes.

Craven Cottage has become an uncomfortable venue for visitors, and Fulham arrives without the pressure of other seasons, allowing them to play with a certain freedom. If they manage to impose their rhythm, they can make the game very difficult.

Chelsea, meanwhile, is still looking for consistency. The team has a solid foundation and performs well away from home, but frequent draws have prevented them from making the definitive leap up the table. Even so, their individual quality and defensive balance give them an advantage in close games like this one.

Fulham vs. Chelsea Betting Pick: Chelsea

Premier League Matchday 21: Manchester City vs. Brighton

Manchester City once again looks like an almost unbeatable team at home. The Etihad remains hostile territory for any opponent, and at this stage of the season, Guardiola’s side seems to have found its best form, with complete control of the game and consistent offensive production.

Brighton arrives with the intention of competing, true to its courageous and collaborative style. However, its away form has been inconsistent, and the margin for error against City is minimal. Any lapse in concentration tends to be costly against a team that punishes with surgical precision.

If City imposes its rhythm from the start, the match could be decided without any surprises.

Manchester City vs. Brighton Betting Pick: Manchester City

Premier League Matchday 21: Arsenal vs. Liverpool

The big match of the day pits two giants with clear objectives against each other. Arsenal comes in as the leader and with a sense of authority not seen in years. Mikel Arteta’s team dominates games through possession, but has also learned to win in complex and tight scenarios.

The Emirates has become a veritable fortress. Arsenal not only wins, but also conveys confidence, maturity, and a clear identity, which is key in the title race.

Liverpool, on the other hand, appears to be a dangerous, albeit inconsistent, opponent. Arne Slot’s team has improved in recent weeks and is unbeaten in its last few games, but it continues to show defensive fragility at key moments. To score in London, it will need a very complete game and maximum concentration.

Arsenal vs. Liverpool Betting Pick: Arsenal