The CONCACAF Champions Cup brings us another chapter of Mexico’s ‘Clásico Nacional’ in the Round of 16, as Guadalajara hosts América.
Guadalajara had some struggles in the first leg but ultimately advanced with a 4-1 aggregate victory over Cibao from the Dominican Republic.
Meanwhile, América did not play in the first phase, as they qualified directly to this Round of 16 by winning the Mexican league title.
Guadalajara vs. Club América Betting Odds and Info
| Guadalajara 3.32 | Club América 2.18 | Draw Offs: 3.42 |
| When? | Wednesday, March 5 at 8:30 pm ET, 7:30 pm CST, 6:30 pm MT, and 5:30 pm PT |
| Where? | Estadio Akron |
| Where Can I Watch It? | fuboTV, Fox Sports 2 |
Why Bet on Guadalajara?
A huge test awaits Guadalajara. After eliminating Cibao from the Dominican Republic, they now face a familiar rival who comes in as the favorite based on their domestic league performance.
Chivas secured a last-minute 1-1 draw in the first leg but comfortably won 3-0 in the second leg at home. However, things aren’t going as smoothly in Liga MX, where they currently sit 10th, with four wins, two draws, and four losses.
They are coming off a 0-1 win against Pumas, thanks to a stoppage-time goal from Luis Gabriel Rey, but they have struggled to put together back-to-back victories in the Clausura MX.
Spanish coach Óscar García, who arrived this season, is already under heavy scrutiny, and this series will be a key test to determine whether he has a long-term future at the club or if his tenure will be cut short sooner than expected.
Why Bet on America?
América is the most successful club in CONCACAF Champions Cup history, with seven titles, but their last triumph came in 2016, making it time for them to reclaim the throne.
The ‘Águilas’ qualified directly for this round thanks to an outstanding 2024 season where they won both the Apertura and Clausura MX tournaments, securing a historic three-peat in Mexican football. Their 2025 campaign started a bit shaky, but they’ve found their rhythm and now sit second in the league, with just one loss, seven wins, and two draws.
With 23 goals, they boast the best attack in the tournament, while their seven goals conceded make them the strongest defense.
They come into this match highly motivated after a dominant 3-0 win over a tough opponent like Toluca. Before that, they also defeated Pumas 0-2 in the Mexico City derby.
Álvaro Fidalgo and Alejandro Zendejas are in top form and stand out as the team’s biggest stars. The Spanish midfielder has recorded four goals and one assist in his last four matches.
Final Betting Analysis: Guadalajara vs. Club América
It’s the Clásico Nacional in the CONCACAF Champions Cup, and despite playing away, América is the clear favorite in this matchup. They arrive in top form, while Guadalajara has been struggling, making us believe that the ‘Águilas’ will take the win.
The odds at Gambyl Exchange favor América, with a Moneyline of 2.18, while Guadalajara stands at 3.32, and a draw is at 3.42.
The last time these two teams faced off was on September 14, 2024, when América won 1-0 with a goal from Ramón Juárez. Their most recent match in Guadalajara ended in a goalless draw.
They also met in the 2024 CONCACAF Champions Cup round of 16, where América won 0-3 as visitors and lost 2-3 at home, advancing with a 5-3 aggregate score.
Go for a straight win for América in the Moneyline. If you bet $100 at 2.18, you will gain $118 for a total payout of $218.
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